Nephrology
Creatinine clearance (Cockcroft-Gault)
Estimate creatinine clearance for drug dosing, where many product labels are still validated.
Version 1976
Inputs
Use ideal or adjusted body weight in obesity.
CrCl (mL/min)
78
Use for dose adjustment where the product label specifies creatinine clearance (e.g. DOACs, enoxaparin, metformin).
- Cockcroft-Gault overestimates in oedema and underestimates in low muscle mass.
Formula
CrCl = ((140 − age) × weight(kg) × (0.85 if female)) / (72 × Scr mg/dL)
Nephron · 1976
Demo content. Educational decision support only. Verify every dose, citation and recommendation against your national formulary and the primary source before clinical use.