KDIGO · Global
KDIGO Clinical Practice Guideline for Acute Kidney Injury
AKI definition and staging, nephrotoxin stewardship and indications for renal replacement therapy.
2012Version 2012 (AKD update 2024)Nephrology
Key recommendations
- GuidelineNot graded
Define AKI as creatinine rise ≥ 0.3 mg/dL in 48 h, ≥ 1.5× baseline in 7 days, or urine output < 0.5 mL/kg/h for 6 h.
- BStrong
Avoid nephrotoxic agents and use isotonic crystalloid rather than colloid for volume expansion.
- GuidelineNot graded
Start renal replacement therapy emergently for life-threatening changes in fluid, electrolyte and acid-base balance.
Applies to
Demo content. Educational decision support only. Verify every dose, citation and recommendation against your national formulary and the primary source before clinical use.